ABSTRACT
The development of vaccines from plants has been going on for over two decades now. Vaccine production in plants requires time and a lot of effort. Despite global efforts in plant-made vaccine development, there are still challenges that hinder the realization of the final objective of manufacturing approved and safe products. Despite delays in the commercialization of plant-made vaccines, there are some human vaccines that are in clinical trials. The novel coronavirus (SARS-CoV-2) and its resultant disease, coronavirus disease 2019 (COVID-19), have reminded the global scientific community of the importance of vaccines. Plant-made vaccines could not be more important in tackling such unexpected pandemics as COVID-19. In this review, we explore current progress in the development of vaccines manufactured in transgenic plants for different human diseases over the past 5 years. However, we first explore the different host species and plant expression systems during recombinant protein production, including their shortcomings and benefits. Lastly, we address the optimization of existing plant-dependent vaccine production protocols that are aimed at improving the recovery and purification of these recombinant proteins.
ABSTRACT
Aims: To identify virtual healthcare services and digital health technologies deployed in South Africa during coronavirus disease 2019 (COVID-19) and the challenges associated with their use. Methods: To determine the status of digital health utilization during COVID-19 in South Africa, the preferred reporting items for systematic reviews and meta-analyses model was used to perform a systematic and in-depth critical analysis of previously published studies in well-known and trusted online electronic databases using specific search keywords words that are relevant to this study. We selected published peer-reviewed articles available from the onset of COVID-19 to July 2021. Results: Total of 24 articles were included into this study. This study revealed that South Africa adopted digital technologies such as SMS-based solutions, mobile health applications, telemedicine and telehealth, WhatsApp-based systems, artificial intelligence and chatbots and robotics to provide healthcare services during COVID-19 pandemic. These innovative technologies have been used for various purposes including screening infectious and non-infectious diseases, disease surveillance and monitoring, medication and treatment compliance, creating awareness and communication. The study also revealed that teleconsultation and e-prescription, telelaboratory and telepharmacy, teleeducation and teletraining, teledermatology, teleradiology, telecardiology, teleophthalmology, teleneurology, telerehabilitation, teleoncology and telepsychiatry are among virtual healthcare services delivered through digital health technologies during COVID-19 in South Africa. However, these smart digital health technologies face several impediments such as infrastructural and technological barriers, organization and financial barriers, policy and regulatory barriers as well as cultural barriers. Conclusion: Although COVID-19 has invigorated the use of digital health technologies, there are still some shortcomings. The outbreak of pandemics like COVID-19 in the future is not inevitable. Therefore, we recommend increasing community networks in rural areas to bridge the digital divide and the modification of mHealth policy to advocate for the effective use of innovative technologies in healthcare and the development of sustainable strategies for resources mobilization through private-public partnerships as well as joining available international initiatives advocating for smart digital health.
ABSTRACT
The adoption of non-invasive smart implants is inevitable due to recent technological advancements in smart implants and the increasing demand to provide pervasive and personalized care. The integration of non-invasive smart implants presents unprecedented opportunities for effective disease prevention, real-time health data collection, early detection of diseases, real-time monitoring of chronic diseases, virtual patient care, patient-tailored treatment, and minimally invasive management of diseases. Even though the research work in this area is nascent, this study presents the potential benefits and use of non-invasive smart implants in healthcare while reflecting on the potential challenges and limitations of their utilization. With current technological advancements, the adoption of non-invasive smart implants is regaining momentum in managing chronic conditions and diseases such as cancer, cardiovascular diseases, cognitive impairment;orthopedic surgery, dental surgery;and managing and remotely monitoring infectious diseases such as the novel coronavirus disease 2019 (COVID-19). However, the full adoption and utilization of non-invasive smart implants still encounter barriers such as lack of policies and frameworks regulating their use, limited memory space, health consequences and implants' failure, clinical challenges, health hazards imposed by non-invasive smart implants, health data security, and privacy risks. Therefore, there is a need for robust security and privacy measures as well as the formulation of policies guiding the development and use of non-invasive smart implants. With the gained experience from smart implants, the next generation of non-invasive smart implants may include sophisticated modern computational techniques that can analyze health data and suggest adequate therapeutic actions.